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Hormone jab joins the obesity wars

A hormone produced in the small intestine after a meal is found to naturally reduce appetite 鈥� test subjects lost several kilograms in four weeks

OVERWEIGHT? Wish you could switch off your appetite? Now a team at Imperial College London has found a hormone that seems to do just that.

The hormone is a peptide known as oxyntomodulin, which is produced by the small intestine after a meal. In a trial, 14 obese and overweight people injected themselves with doses of the hormone 30 minutes before breakfast, lunch and dinner. After four weeks they had lost an average of 2.3 kilograms, compared with 0.5 kg for the control group (Diabetes, DOI: 54.08.05.db05-0480).

鈥淲e are fooling the brain, in a very natural way, into thinking it has just eaten a meal and is no longer hungry,鈥� says Steve Bloom, who led the trials.

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