Never mind the bitter end 鈥� it is the bitter beginning of an infection that triggers an immune response.
We know that taste receptors on the tongue can detect bitter foods, but it turns out that there are also identical taste receptors in the upper airway. at the University of Pennsylvania in Philadelphia and his team think they know why.
They grew cell cultures from sinus tissue samples collected from surgical patients, and found that bitter taste receptors in the tissue picked up the presence of , a bacterium that can cause pneumonia. The sinus tissue responded by producing nitric oxide to kill the invading microbes.
Advertisement
鈥淐ertain people have strong innate defences against these bacteria, which is based on their ability to detect bitterness,鈥� says Cohen. 鈥淥thers who don鈥檛 really 鈥榯aste鈥� these bitter compounds have a weakened defence.鈥�
The research could lead to nasal sprays designed to activate the taste receptors and boost people鈥檚 natural defences against sinus infections.
鈥淭his is probably the most exciting clinical link found for bitter receptors,鈥� says of the Monell Chemical Senses Center in Philadelphia, Pennsylvania, who was not involved in the study. 鈥淗owever, further work is needed to see if this can be translated into treatments.鈥�
Journal reference:
